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KMID : 0360419670030010043
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Korean Journal of Pharmacology
1967 Volume.3 No. 1 p.43 ~ p.49
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Supplemental studies on the adrenotropic receptors of the rat uterus
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Abstract
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Supplemental studies were made on the adrenotropic receptors of the rat uterus, using adrenergic activators sucth as phenylephrine, norepinephrine, epinephrine, and isoproterenol and adrenergic blocking agents such as phenoxybenzamine and inderal. The studies have revealed the following results:
1. Phenylephrine, norepinephrine, epinephrine, and isoproterenol inhibited the spontaneous motility of the isolated rat uterus in the following order:
Isoproterenol>epinephrine>norepinephrine>phenylephrine.
2. The inhibitory responses of the isolated rat uterus to phenylephrine and norepinephrine were abolished by the pretreatment with phenoxybenzamine.
3. The inhibitory responses of the isolated rat uierus to isoproterenol and epinephrine were not affected by phenoxybenzamine.
4. The motility of the isolated rat uterus pretreated with inderal was stimulated by phenylephrine, norepinephrine and epinephrine.
5. The intibitory responses of the isolated rat uterus to isoproterenol were abolished by the pretreatment with inderal.
6. The motility of the isolated rat uterus pretreated with inderal and phenoxybenzamine was not affected by phenylephrine, norepinephrine and epinephrine.
7. It is, therefore, concluded that the rat uterus has both alpha excitatory and beta inhibitory receptors, with beta inhlbitory receptors predominating.
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